Next Pharmaceuticals launched its first product in 1999 with Nexrutine, the original anti-inflammatory. Its mechanism of action was unique then and is still set apart from the countless anti-inflammatories now available. Nexrutine inhibits the gene expression of the COX-2 enzyme through its proprietary blend of actives extracted from the bark of Phellodendron amurense. This is an indirect inhibition of the enzyme, differentiating itself from all other COX-2 inhibitors. Nexrutine does not promote any of the negative side effects associated with COX-2 inhibition. In fact, the natural proprietary extract found in Nexrutine has been shown to have cardio-protective properties.
In 2004, a double-blind, placebo-controlled trial investigating the benefits of Nexrutine in 28 subjects with serious joint pain was conducted. The Nexrutine group significantly improved on total quality of life measurements, whereas the placebo group did not. The total post-treatment scores on the Quality of Life instrument (SF-36v2) were improved significantly from the pre-treatment scores in the Nexrutine group for Role Physical, Vitality, Mental Health and Mental Component Summary. Of particular importance, the Nexrutine group showed significant improvements on these measures over the course of the study, while there were no changes in the placebo group.
Nexrutine has been shown in an in-home-use-trial, the type of trial used to demonstrate safety and efficacy for over-the-counter (OTC) drugs, to be a safe, effective and rapidly acting dietary supplement which helps avoid or relieve the general aches and pains associated with physical activity or over-exertion. Fifty-three subjects were treated with Nexrutine for two weeks. The recommended dosage was 250mg Nexrutine three times daily. Post-trial analysis revealed an excellent agreement (79%) with the pretrial concept that Nexrutine helps avoid or relieve general aches and pains associated with physical activity or over-exertion. Overall effectiveness was reported by 72% of the patients. The efficacy parameters for Nexrutine included the following; eases soreness in joints and muscles and makes everyday activities more comfortable. Nexrutine was judged to be gentle on the stomach by 86% of the subjects.
Marketed to help alleviate aches and pains associated with physical activity, exercise and over-exertion, Nexrutine works fast. It is ideal to help promote recovery for those whose workouts are intense. It is perfect in combination with other ingredients that help to rebuild cartilage and lubricate joints. As recently as 2007, a Nexrutine article appeared in Woman’s World, one of the most popular women’s magazines sold in virtually every grocery and chain drug store. Nexrutine is a must for joint products that promote recovery from exercise and over-exertion.