Citri-Z is the only patented (US Patent Nos. 6,184,246 and 6,987,125) proprietary blend that exclusively provides polymethoxylated flavones (PMF) and other bioflavonoids. The anti-inflammatory benefits of Citri-Z are unique to its proprietary composition and are unlikely to be found in other PMF products.
Citri-Z inhibits tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory cytokine. Overproduction of TNF-alpha, particularly if sustained for long periods of time, has been associated with the development of heart disease. As a key mediator of systemic inflammation, TNF-alpha has been linked not only to high cholesterol and heart disease, but many other debilitating diseases. Lowering TNF-alpha has a direct effect on decreasing levels of C-reactive protein, which is a clear indicator of systemic inflammation
Research has shown that lowering TNF-α has a beneficial effect on cholesterol levels. The simplest way to mediate this dangerous cytokine is to ensure the diet provides a high level of PMF. Unfortunately, PMF is not found in sufficient amounts in the food supply. Citri-Z provides high levels of tangeretin and nobiletin, two PMFs that have been extensively studied for their ability to help lower low-density lipoprotein cholesterol (LDL-C). These PMFs have demonstrated the ability to inhibit apolipoprotein B (ApoB) production, essential for the formation of LDL-C.
A study was published in 2012 that examined the effects of flavonoid subclasses on the risk level of different types of stroke in women. The results suggested that flavanones from citrus fruit may be associated with a reduced risk of ischemic stroke.
When diet is not enough, Citri-Z is the answer. Ideal for tablets, capsules and soft gels, it can be formulated as a standalone dietary supplement or blended with other natural ingredients that support heart health.